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īrow ridge and forehead protrusion remaining after tumor removal and tissue swelling eliminatedįeatures that may result from a high level of GH or expanding tumor include: The term is from the Greek ἄκρον ( akron) meaning "extremity", and μέγα ( mega) meaning "large". It was first described in the medical literature by Nicolas Saucerotte in 1772.

Males and females are affected with equal frequency. It is most commonly diagnosed in middle age. Īcromegaly affects about 3 per 50,000 people. Without treatment, life expectancy is reduced by 10 years with treatment, life expectancy is not reduced. Radiation therapy may be used if neither surgery nor medications are completely effective. If surgery is contraindicated or not curative, somatostatin analogues or GH receptor antagonists may be used. Surgery is usually the preferred treatment the smaller the tumor, the more likely surgery will be curative. Treatment options include surgery to remove the tumor, medications, and radiation therapy. If excess growth hormone is produced during childhood, the result is the condition gigantism rather than acromegaly. After diagnosis, medical imaging of the pituitary is carried out to determine if an adenoma is present. Diagnosis is by measuring growth hormone after a person has drunk a glucose solution, or by measuring insulin-like growth factor I in the blood. Acromegaly is rarely due to a tumor in another part of the body. The condition is not inherited from a person's parents. In more than 95% of cases the excess production is due to a benign tumor, known as a pituitary adenoma. Īcromegaly is usually caused by the pituitary gland producing excess growth hormone. Complications of the disease may include type 2 diabetes, sleep apnea, and high blood pressure. Other symptoms may include joint pain, thicker skin, deepening of the voice, headaches, and problems with vision. There may also be an enlargement of the forehead, jaw, and nose. The initial symptom is typically enlargement of the hands and feet. Usually normal (with treatment), 10 year shorter life expectancy (no treatment) Īcromegaly is a disorder that results from excess growth hormone (GH) after the growth plates have closed. Somatostatin analogue, GH receptor antagonist Type 2 diabetes, sleep apnea, high blood pressure